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This study demonstrated that ERT not only ameliorated structural deformities but also reduced oxidative stress and increased the gene expression of kidney cells in Fabry kidney organoids, which means that Fabry kidney organoids are useful tools for investigating the efficacy of ERT and will contribute to the development of new forms of ERT

PMID: 38252220 Maghbooli M, Alyan NajafAbadi S, MalekMahmoudi G, Molseghi MH (2023) Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial

Information on Chinese medicine preparations and clinical reports was also integrated to provide an overview of modern applications and safety considerations

Serious but rare adverse events include severe hypoglycaemia, pancreatitis, and allergic reactions